PUBLICATIONS
Recent Publications
Can AI be an inventor in materials discovery?
G. A. Ozin*, C. Qian* & J. G. MacIntosh, Matter (2023), accepted.
In this article, three faculty members at the University of Toronto in the fields of energy materials discovery for a sustainable future, machine-learning-aided biomedical science, and corporation law, finance, and securities regulation ask and discuss the question visible in many aspects of our lives: ‘‘In the process of discovery, can AI be an inventor on a patent and an owner of intellectual property?’’
Super-Resolution Label-free Volumetric Vibrational Imaging
C. Qian†, K. Miao†, L. Lin, X. Chen, J. Du, L. Wei*, Nature Communications, 3648 (2021).
“Microscopy method achieves superresolution without labels”, featured by C&EN.
High spatial-resolution imaging of label-free in vivo protein aggregates by VISTA
L. Lin, K. Miao, C. Qian, L. Wei*, Analyst, 146, 4135-4145 (2021).
Label-free Super-resolution Imaging Enabled by Vibrational Imaging of Swelled Tissue and Analysis
K. Miao, L. Lin, C. Qian & L. Wei*, J. Vis. Exp. (183), e63824, (2022).
Toward Photoswitchable Pre-resonance Stimulated Raman Probes
D. Lee, C. Qian, H. Wang, L. Lei, K. Miao, J. Du, D. M. Shcherbakova, V. V. Verkhusha, L.V. Wang, and L. Wei*, Journal of Chemical Physics, 154, 135102, (2021).
Raman-guided Subcellular Pharmaco-Metabolomics for Metastatic Melanoma Cells
J. Du†, Y. Su†, C. Qian, D. Yuan, K. Miao, D. Lee, A. Ng, R. Wijker, A. Ribas, R. Levine, J. Heath*, and L. Wei*, Nature Communications, 11, 4830, (2020).
"Cancer’s hidden vulnerabilities"
Past Publications
Chenxi Qian’s google scholar page:
https://scholar.google.com/citations?user=pZED_kwAAAAJ
Quantitative Real-Time Analysis of Living Materials by Stimulated Raman Scattering Microscopy
Chenxi Qian Hanwei Liu Priya K. Chittur Rahuljeet S. Chadha Yuxing Yao Julia A. Kornfield David A. Tirrell* Lu Wei*
Anal. Chem. 2024, 96, 17, 6540–6549
In this report we established a strategy based on stimulated Raman scattering microscopy to monitor phosphatase-catalyzed mineralization of engineered bacterial films in situ. Real-time label-free imaging elucidates the mineralization process, quantifies both the organic and inorganic components of the material as functions of time, and reveals spatial heterogeneity at multiple scales. In addition, we correlate the mechanical performance of films with the extent of mineralization. This work introduces a promising strategy for quantitatively analyzing living materials, which should contribute to the accelerated development of such materials in the future.
(cover article / cover art design: Chenxi Qian)
